This article highlights how Propath uses the COMET™ multiplex immunofluorescence platform to help biopharma companies maximize biological insights from limited clinical trial tissue samples. By combining automated staining, high-plex protein analysis, customisable antibody panels, and integration with spatial transcriptomics workflows, COMET enables researchers to generate rich, multiomic datasets from a single tissue section, supporting biomarker discovery, mechanism-of-action studies, and translational research.