RNAscope™ is a powerful multiplex fluorescent and chromogenic in situ hybridization technology, enabling detection and quantification of target RNA within intact cells.
With its proprietary probe design, the technology enables simultaneous amplification of target-specific signals and suppression of background noise from non-specific hybridization.
RNAscope, complements microarray and PCR by retaining clinically relevant cellular and tissue context, as well as spatial variation of expression patterns.
A complete managed service for RNAscope, BaseScope™ in situ hybridization: from study design and sample prep through to quantitative data analysis.
Simply send us your samples and receive publication ready data in as little as four weeks.
RNAscope in situ hybridization is being used by researchers to complement IHC and as an effective alternative to IHC
In order to substantially improve the signal-to-noise ratio of RNA ISH, RNAscope requires two independent probes (double Z probes) to hybridize to the target sequence in tandem in order for signal amplification to occur.
As it is highly unlikely that two independent probes will hybridize to a non-specific target right next to each other, this design concept ensures selective amplification of target-specific signals.
Our experience across a range of platforms for spatial biology allows us to recommend the most appropriate platform for each research project.
We understand the strengths and limitations of each platform – and how to get the best out of them.