The GeoMx DSP resolves the trade-off between spatial and high-plex analysis, providing deeper insights into the biology of heterogeneous tissues.
From discovery to translational research, spatial analysis with the NanoString GeoMX is efficient, reproducible and reveals the full complexity of the tumour microenvironment.
Understanding tissue heterogeneity is critical to answering key biological questions. The current tissue analysis paradigm requires a trade-off between low-plex spatial analysis or high-plex bulk analysis, sacrificing valuable information and consuming precious samples.
NanoString’s GeoMx Digital Spatial Profiler (DSP) combines the best of spatial and molecular profiling technologies by generating a whole tissue image at single cell resolution and digital profiling data for 10’s-1,000’s of RNA or Protein analytes.
This unique combination of high-plex and high-throughput spatial profiling enables researchers to rapidly and quantitatively assess the biological implications of the heterogeneity within tissue samples.
The GeoMx DSP is a novel platform developed by NanoString. Digital spatial profiling is based on nCounter barcoding technology and enables spatially resolved, digital readout of up to 96 proteins or RNA targets in a multiplexed assay.
The assay relies upon antibody or RNA probes coupled to photocleavable oligonucleotide tags. After hybridization of probes to slide-mounted FFPE tissue sections, the oligonucleotide tags are released from discrete regions of the tissue via UV exposure.
Released tags are quantitated in a standard nCounter assay, and counts are mapped back to tissue location, yielding a spatially-resolved digital profile of analyte abundance.
We take care of the complete process from sample preparation to data analysis, with robust QA procedures and complete traceability of your precious samples.
The essential tool for spatial genomics in oncology
The GeoMx Cancer Transcriptome Atlas (CTA) is designed for comprehensive profiling of tumour biology, the tumour microenvironment, and the immune response.
Profile RNA expression of over 1,800 genes simultaneously with spatial resolution from distinct regions of interest with just a single tissue section.
Spatial analysis of 18,000+ genes in any tissue in the biological regions that matter most
The GeoMx Whole Transcriptome Atlas (WTA) is designed for comprehensive profiling of spatial biology. With full coverage of protein coding genes, WTA delivers spatial analysis of any target in any tissue in any region of interest.